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Medical–Financial Partnerships — Beyond Traditional Boundaries
Lucy E. Marcil, M.D., M.P.H., Katherine G. Barnett, M.D., and Barry Zuckerman, M.D.
doi : 10.1056/NEJMp2101731
N Engl J Med 2021; 385:289-291
Virchow at 200 and Lown at 100 — Physicians as Activists
Salvatore Mangione, M.D., and Mark L. Tykocinski, M.D.
doi : 10.1056/NEJMp2103050
N Engl J Med 2021; 385:291-293
One Hundred Years of Insulin for Some
Amy Moran-Thomas, Ph.D.
doi : 10.1056/NEJMp2105697
N Engl J Med 2021; 385:293-295
Multivessel PCI Guided by FFR or Angiography for Myocardial Infarction
Etienne Puymirat, M.D., Ph.D., Guillaume Cayla, M.D., Ph.D., Tabassome Simon, M.D., Ph.D., Philippe G. Steg, M.D., Gilles Montalescot, M.D., Ph.D., Isabelle Durand-Zaleski, M.D., Ph.D., Alicia le Bras, M.D., Romain Gallet, M.D., Ph.D., Khalife Khalife, M.D., Jean-François Morelle, M.D., Pascal Motreff, M.D., Ph.D., Gilles Lemesle, M.D., Ph.D., et al., for the FLOWER-MI Study Investigators*
doi : 10.1056/NEJMoa2104650
N Engl J Med 2021; 385:297-308
In patients with ST-elevation myocardial infarction (STEMI) who have multivessel disease, percutaneous coronary intervention (PCI) for nonculprit lesions (complete revascularization) is superior to treatment of the culprit lesion alone. However, whether complete revascularization that is guided by fractional flow reserve (FFR) is superior to an angiography-guided procedure is unclear.
Trial of Pimavanserin in Dementia-Related Psychosis
Pierre N. Tariot, M.D., Jeffrey L. Cummings, M.D., Sc.D., Maria E. Soto-Martin, M.D., Ph.D., Clive Ballard, M.D., Deniz Erten-Lyons, M.D., David L. Sultzer, M.D., Davangere P. Devanand, M.D., Daniel Weintraub, M.D., Bradley McEvoy, Dr.P.H., James M. Youakim, M.D., Srdjan Stankovic, M.D., M.S.P.H., and Erin P. Foff, M.D., Ph.D.
doi : 10.1056/NEJMoa2034634
N Engl J Med 2021; 385:309-319
Patients with dementia due to neurodegenerative disease can have dementia-related psychosis. The effects of the oral 5-HT2A inverse agonist and antagonist pimavanserin on psychosis related to various causes of dementia are not clear.
Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines
Mark G. Thompson, Ph.D., Jefferey L. Burgess, M.D., M.P.H., Allison L. Naleway, Ph.D., Harmony Tyner, M.D., M.P.H., Sarang K. Yoon, D.O., Jennifer Meece, Ph.D., Lauren E.W. Olsho, Ph.D., Alberto J. Caban-Martinez, D.O., Ph.D., M.P.H., C.P.H., Ashley L. Fowlkes, Sc.D., M.P.H., Karen Lutrick, Ph.D., Holly C. Groom, M.P.H., Kayan Dunnigan, M.P.H., Marilyn J. Odean, M.S., Kurt Hegmann, M.D., Elisha Stefanski, B.S., Laura J. Edwards, M.P.H., Natasha Schaefer-Solle, Ph.D., Lauren Grant, M.S., Katherine Ellingson, Ph.D., Jennifer L. Kuntz, Ph.D., Tnelda Zunie, B.S., Matthew S. Thiese, Ph.D., Lynn Ivacic, B.S., Meredith G. Wesley, M.P.H., Julie Mayo Lamberte, M.S.P.H., Xiaoxiao Sun, Ph.D., Michael E. Smith, B.S., Andrew L. Phillips, M.D., Kimberly D. Groover, Ph.D., Young M. Yoo, M.S.P.H., Joseph Gerald, M.D., Rachel T. Brown, Ph.D., Meghan K. Herring, M.P.H., Gregory Joseph, M.P.H., Shawn Beitel, M.Sc., Tyler C. Morrill, M.S., Josephine Mak, M.P.H., Patrick Rivers, M.P.P., Brandon P. Poe, M.P.A., Brian Lynch, B.S.,Yingtao Zhou, Ph.D., Jing Zhang, Ph.D., Anna Kelleher, M.S., Yan Li, B.S., Monica Dickerson, B.S., Erika Hanson, M.S., Kyley Guenther, B.S., Suxiang Tong, Ph.D., Allen Bateman, Ph.D., Erik Reisdorf, M.P.H., John Barnes, Ph.D., Eduardo Azziz-Baumgartner, M.D., Danielle R. Hunt, Ph.D., Melissa L. Arvay, Ph.D., M.P.H., Preeta Kutty, M.D., Alicia M. Fry, M.D., M.P.H., and Manjusha Gaglani, M.B.B.S.
doi : 10.1056/NEJMoa2107058
N Engl J Med 2021; 385:320-329
Information is limited regarding the effectiveness of the two-dose messenger RNA (mRNA) vaccines BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna) in preventing infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in attenuating coronavirus disease 2019 (Covid-19) when administered in real-world conditions.
Dolutegravir or Darunavir in Combination with Zidovudine or Tenofovir to Treat HIV
Nicholas I. Paton, M.D., Joseph Musaazi, M.Sc., Cissy Kityo, Ph.D., Stephen Walimbwa, M.D., Anne Hoppe, Ph.D., Apolo Balyegisawa, M.D., Arvind Kaimal, M.D., Grace Mirembe, M.Med., Phionah Tukamushabe, R.N., Gilbert Ategeka, M.D., James Hakim, F.R.C.P., Henry Mugerwa, M.D., Abraham Siika, M.Med., Jesca Asienzo, B.P.L.M., Barbara Castelnuovo, Ph.D., Agnes Kiragga, Ph.D., and Andrew Kambugu, M.Med. for the NADIA Trial Team*
doi : 10.1056/NEJMoa2101609
N Engl J Med 2021; 385:330-341
The World Health Organization recommends dolutegravir with two nucleoside reverse-transcriptase inhibitors (NRTIs) for second-line treatment of human immunodeficiency virus type 1 (HIV-1) infection. Evidence is limited for the efficacy of this regimen when NRTIs are predicted to lack activity because of drug resistance, as well as for the recommended switch of an NRTI from tenofovir to zidovudine.
Racial Inequality in Prescription Opioid Receipt — Role of Individual Health Systems
Nancy E. Morden, M.D., Deanna Chyn, M.P.H., Andrew Wood, M.P.H., and Ellen Meara, Ph.D.
doi : 10.1056/NEJMsa2034159
N Engl J Med 2021; 385:342-351
Historically, the receipt of prescription opioids has differed among racial groups in the United States. Research has not sufficiently explored the contribution of individual health systems to these differences by examining within-system prescription opioid receipt according to race.
Substance Use among Men Who Have Sex with Men
Wilson M. Compton, M.D., M.P.E., and Christopher M. Jones, Pharm.D., Dr.P.H.
doi : 10.1056/NEJMra2033007
N Engl J Med 2021; 385:352-356
Salt-and-Pepper Skin Changes in Systemic Sclerosis
Matthew Colquhoun, M.R.C.P., and Henry Penn, F.R.C.P.
doi : 10.1056/NEJMicm2103390
N Engl J Med 2021; 385:357
Acute Febrile Neutrophilic Dermatosis
Ali M. Ayyash, M.D., M.P.H., and Rahul Sampath, M.D.
doi : 10.1056/NEJMicm2033219
N Engl J Med 2021; 385:e14
Case 22-2021: A 64-Year-Old Woman with Cognitive Impairment, Headache, and Memory Loss
Shamik Bhattacharyya, M.D., R. Gilberto Gonzalez, M.D., Bart K. Chwalisz, M.D., and Samantha N. Champion, M.D.
doi : 10.1056/NEJMcpc2103460
N Engl J Med 2021; 385:358-368
PCI for Nonculprit Lesions in Patients with STEMI — No Role for FFR
Peter Jüni, M.D.
doi : 10.1056/NEJMe2108328
N Engl J Med 2021; 385:370-371
Pimavanserin in Dementia-Related Psychosis
Joseph I. Friedman, M.D.
doi : 10.1056/NEJMe2109010
N Engl J Med 2021; 385:372-373
Audio Interview: The Impact of Covid-19 on Trainees and Junior Faculty
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Katrina A. Armstrong, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2112375
N Engl J Med 2021; 385:e21
Covid-19 Vaccine Acceptance in California State Prisons
doi : 10.1056/NEJMc2105282
N Engl J Med 2021; 385:374-376
PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia
doi : 10.1056/NEJMc2106383
N Engl J Med 2021; 385:376-378
Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality
doi : 10.1056/NEJMc2107926
N Engl J Med 2021; 385:378-380
