New England Journal of Medicine




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Addressing Vaccine Hesitancy in BIPOC Communities — Toward Trustworthiness, Partnership, and Reciprocity

Sandra C. Quinn, Ph.D., and Michele P. Andrasik, Ph.D.

doi : 10.1056/NEJMp2103104

N Engl J Med 2021; 385:97-100

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Beyond the First Dose — Covid-19 Vaccine Follow-through and Continued Protective Measures

Jillian L. Goldfarb, Ph.D., Sarah Kreps, Ph.D., John S. Brownstein, Ph.D., and Douglas L. Kriner, Ph.D.

doi : 10.1056/NEJMp2104527

N Engl J Med 2021; 385:101-103

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The CT Scan after 50 years — Continuity and Change

Joel D. Howell, M.D., Ph.D.

doi : 10.1056/NEJMp2033374

N Engl J Med 2021; 385:104-105

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Randomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia

Jan A. Deprest, M.D., Ph.D., Kypros H. Nicolaides, M.D., Alexandra Benachi, M.D., Ph.D., Eduard Gratacos, M.D., Ph.D., Greg Ryan, M.D., Nicola Persico, M.D., Ph.D., Haruhiko Sago, M.D., Ph.D., Anthony Johnson, M.D., Miros?aw Wielgo?, M.D., Ph.D., Christoph Berg, M.D., Ph.D., Ben Van Calster, Ph.D., and Francesca M. Russo, M.D., Ph.D. for the TOTAL Trial for Severe Hypoplasia Investigators*

doi : 10.1056/NEJMoa2027030

N Engl J Med 2021; 385:107-118

Observational studies have shown that fetoscopic endoluminal tracheal occlusion (FETO) has been associated with increased survival among infants with severe pulmonary hypoplasia due to isolated congenital diaphragmatic hernia on the left side, but data from randomized trials are lacking.

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Randomized Trial of Fetal Surgery for Moderate Left Diaphragmatic Hernia

Jan A. Deprest, M.D., Ph.D., Alexandra Benachi, M.D., Ph.D., Eduard Gratacos, M.D., Ph.D., Kypros H. Nicolaides, M.D., Christoph Berg, M.D., Ph.D., Nicola Persico, M.D., Ph.D., Michael Belfort, M.D., Ph.D., Glenn J. Gardener, M.D., Ph.D., Yves Ville, M.D., Ph.D., Anthony Johnson, M.D., Francesco Morini, M.D., Ph.D., Miros?aw Wielgo?, M.D., Ph.D., et al., for the TOTAL Trial for Moderate Hypoplasia Investigators*

doi : 10.1056/NEJMoa2026983

N Engl J Med 2021; 385:119-129

Fetoscopic endoluminal tracheal occlusion (FETO) has been associated with increased postnatal survival among infants with severe pulmonary hypoplasia due to isolated congenital diaphragmatic hernia on the left side, but data are lacking to inform its effects in infants with moderate disease.

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Bimekizumab versus Adalimumab in Plaque Psoriasis

Richard B. Warren, M.D., Ph.D., Andrew Blauvelt, M.D., Jerry Bagel, M.D., Kim A. Papp, M.D., Ph.D., Paul Yamauchi, M.D., Ph.D., April Armstrong, M.D., M.P.H., Richard G. Langley, M.D., Veerle Vanvoorden, M.Sc., Dirk De Cuyper, M.D., Christopher Cioffi, Ph.D., Luke Peterson, M.S., Nancy Cross, M.D., and Kristian Reich, M.D., Ph.D.

doi : 10.1056/NEJMoa2102388

N Engl J Med 2021; 385:130-141

Bimekizumab is a monoclonal IgG1 antibody that selectively inhibits interleukin-17A and interleukin-17F. The efficacy and safety of bimekizumab as compared with the tumor necrosis factor inhibitor adalimumab in patients with moderate-to-severe plaque psoriasis have not been extensively examined.

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Bimekizumab versus Secukinumab in Plaque Psoriasis

Kristian Reich, M.D., Ph.D., Richard B. Warren, M.D., Ph.D., Mark Lebwohl, M.D., Melinda Gooderham, M.D., Bruce Strober, M.D., Ph.D., Richard G. Langley, M.D., Carle Paul, M.D., Ph.D., Dirk De Cuyper, M.D., Veerle Vanvoorden, M.Sc., Cynthia Madden, M.D., Christopher Cioffi, Ph.D., Luke Peterson, M.S., and Andrew Blauvelt, M.D.

doi : 10.1056/NEJMoa2102383

N Engl J Med 2021; 385:142-152

Bimekizumab is a monoclonal IgG1 antibody that selectively inhibits both interleukin-17A and interleukin-17F. The efficacy and safety of bimekizumab as compared with secukinumab, which selectively inhibits interleukin-17A alone, in patients with moderate-to-severe plaque psoriasis have not been extensively examined.

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Hematuria in Adults

Julie R. Ingelfinger, M.D.

doi : 10.1056/NEJMra1604481

N Engl J Med 2021; 385:153-163

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Malar Rash

Sarah E. Goglin, M.D., and Mary E. Margaretten, M.D., M.A.S.

doi : 10.1056/NEJMicm2029589

N Engl J Med 2021; 385:164

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Phthiriasis Palpebrarum

Xue Feng, M.D., and Hong Qi, M.D.

doi : 10.1056/NEJMicm1913478

N Engl J Med 2021; 385:e5

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Case 20-2021: A 69-Year-Old Man with Ataxia

Vikram Khurana, M.B., B.S., Ph.D., Claudio M. de Gusmao, M.D., McKinley Glover, M.D., and Jeffrey Helgager, M.D., Ph.D.

doi : 10.1056/NEJMcpc2004992

N Engl J Med 2021; 385:165-175

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Fetal Tracheal Occlusion for Congenital Diaphragmatic Hernia

F. Sessions Cole, M.D.

doi : 10.1056/NEJMe2107446

N Engl J Med 2021; 385:177-178

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Audio Interview: How Well Are Covid-19 Vaccines Working?

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2111369

N Engl J Med 2021; 385:e15

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SARS-CoV-2 Variants and Vaccines

Philip R. Krause, M.D., Thomas R. Fleming, Ph.D., Ira M. Longini, Ph.D., Richard Peto, F.R.S., Sylvie Briand, M.D., David L. Heymann, M.D., Valerie Beral, F.R.C.P., Matthew D. Snape, M.D., Helen Rees, M.R.C.G.P., Alba-Maria Ropero, B.Sc., Ran D. Balicer, M.D., Jakob P. Cramer, M.D., et al.

doi : 10.1056/NEJMsr2105280

N Engl J Med 2021; 385:179-186

Viral variants of concern may emerge with dangerous resistance to the immunity generated by the current vaccines to prevent coronavirus disease 2019 (Covid-19). Moreover, if some variants of concern have increased transmissibility or virulence, the importance of efficient public health measures and vaccination programs will increase. The global response must be both timely and science based.

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Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants

doi : 10.1056/NEJMc2104974

N Engl J Med 2021; 385:187-189

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PTH Infusion for Seizures in Autosomal Dominant Hypocalcemia Type 1

doi : 10.1056/NEJMc2034981

N Engl J Med 2021; 385:189-191

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Moving beyond “Red Man Syndrome”

doi : 10.1056/NEJMc2107779

N Engl J Med 2021; 385:192

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Semaglutide or Placebo for Nonalcoholic Steatohepatitis

doi : 10.1056/NEJMc2106921

N Engl J Med 2021; 385:e6

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Vaccine Breakthrough Infections with SARS-CoV-2 Variants

doi : 10.1056/NEJMc2107808

N Engl J Med 2021; 385:e7

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More on SARS-CoV-2 Infection after Vaccination in Health Care Workers

doi : 10.1056/NEJMc2106004

N Engl J Med 2021; 385:e8

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