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Advancing the Learning Health System
J. Michael McGinnis, M.D., M.P.P., Harvey V. Fineberg, M.D., Ph.D., and Victor J. Dzau, M.D.
doi : 10.1056/NEJMp2103872
N Engl J Med 2021; 385:1-5
Is Learning Worth the Trouble? — Improving Health Care System Participation in Embedded Research
Richard Platt, M.D., Gregory E. Simon, M.D., and Adrian F. Hernandez, M.D.
doi : 10.1056/NEJMp2101700
N Engl J Med 2021; 385:5-7
Covid-19 and the Investigator Pipeline
Katrina Armstrong, M.D., M.S.C.E.
doi : 10.1056/NEJMp2100086
N Engl J Med 2021; 385:7-9
Incentives for Immunity — Strategies for Increasing Covid-19 Vaccine Uptake
Kevin G. Volpp, M.D., Ph.D., and Carolyn C. Cannuscio, Sc.D.
doi : 10.1056/NEJMp2107719
N Engl J Med 2021; 385:e1
Protecting Olympic Participants from Covid-19 — The Urgent Need for a Risk-Management Approach
Annie K. Sparrow, M.D., M.P.H., Lisa M. Brosseau, Sc.D., Robert J. Harrison, M.D., M.P.H., and Michael T. Osterholm, Ph.D., M.P.H.
doi : 10.1056/NEJMp2108567
N Engl J Med 2021; 385:e2
Treatment of Multisystem Inflammatory Syndrome in Children
Andrew J. McArdle, M.B., B.Chir., Ortensia Vito, M.Sc., Harsita Patel, M.B., B.S., Eleanor G. Seaby, B.M., B.S., Priyen Shah, M.B., B.S., Clare Wilson, M.B., B.Chir., Claire Broderick, M.B., B.S., Ruud Nijman, M.D., Ph.D., Adriana H. Tremoulet, M.D., Daniel Munblit, M.D., Ph.D., Rolando Ulloa-Gutierrez, M.D., Michael J. Carter, B.M., B.Ch., D.Phil., et al., for the BATS Consortium*
doi : 10.1056/NEJMoa2102968
N Engl J Med 2021; 385:11-22
Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2.
Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes
Mary Beth F. Son, M.D., Nancy Murray, M.Sc., Kevin Friedman, M.D., Cameron C. Young, Margaret M. Newhams, M.P.H., Leora R. Feldstein, Ph.D., Laura L. Loftis, M.D., Keiko M. Tarquinio, M.D., Aalok R. Singh, M.D., Sabrina M. Heidemann, M.D., Vijaya L. Soma, M.D., Becky J. Riggs, M.D., et al., for the Overcoming COVID-19 Investigators*
doi : 10.1056/NEJMoa2102605
N Engl J Med 2021; 385:23-34
The assessment of real-world effectiveness of immunomodulatory medications for multisystem inflammatory syndrome in children (MIS-C) may guide therapy.
A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease
Detlef Schuppan, M.D., Ph.D., Markku M?ki, M.D., Ph.D., Knut E.A. Lundin, M.D., Ph.D., Jorma Isola, M.D., Ph.D., Tina Friesing-Sosnik, M.D., Juha Taavela, M.D., Ph.D., Alina Popp, M.D., Ph.D., Jari Koskenpato, M.D., Jost Langhorst, M.D., ?istein Hovde, M.D., Ph.D., Marja-Leena L?hdeaho, M.D., Ph.D., Stefano Fusco, M.D., et al., for the CEC-3 Trial Group*
doi : 10.1056/NEJMoa2032441
N Engl J Med 2021; 385:35-45
In celiac disease, small intestinal transglutaminase 2 causes deamidation of glutamine residues in gluten peptides, which enhances stimulation of T cells and leads to mucosal injury. Inhibition of transglutaminase 2 is a potential treatment for celiac disease.
Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis
Efstathios Kastritis, M.D., Giovanni Palladini, M.D., Monique C. Minnema, M.D., Ashutosh D. Wechalekar, M.D., Arnaud Jaccard, M.D., Hans C. Lee, M.D., Vaishali Sanchorawala, M.D., Simon Gibbs, M.B., B.S., Peter Mollee, M.B., B.S., Christopher P. Venner, M.D., Jin Lu, M.D., Stefan Sch?nland, M.D., et al., for the ANDROMEDA Trial Investigators*
doi : 10.1056/NEJMoa2028631
N Engl J Med 2021; 385:46-58
Systemic immunoglobulin light-chain (AL) amyloidosis is characterized by deposition of amyloid fibrils of light chains produced by clonal CD38+ plasma cells. Daratumumab, a human CD38-targeting antibody, may improve outcomes for this disease.
Cerebral Venous Thrombosis
Allan H. Ropper, M.D., and Joshua P. Klein, M.D., Ph.D.
doi : 10.1056/NEJMra2106545
N Engl J Med 2021; 385:59-64
Lingual-Artery Thromboembolism
Robert Humphries, M.B., B.Chir., and Malcolm Cameron, M.B., B.S., B.D.S.
doi : 10.1056/NEJMicm2028154
N Engl J Med 2021; 385:65
Perivalvular Abscess Causing Coronary-Artery Compression
Daniel L. Varela, M.D., and Tara L. Jones, M.D., Pharm.D.
doi : 10.1056/NEJMicm2029179
N Engl J Med 2021; 385:e3
A Brewing Back Pain
Lauren Pischel, M.D., Arnar Geirsson, M.D., John Magaldi, M.D., Richard A. Martinello, M.D., and Alfred I. Lee, M.D., Ph.D.
doi : 10.1056/NEJMcps2034802
N Engl J Med 2021; 385:66-72
Immunotherapy for MIS-C — IVIG, Glucocorticoids, and Biologics
Roberta L. DeBiasi, M.D.
doi : 10.1056/NEJMe2108276
N Engl J Med 2021; 385:74-75
Transglutaminase 2 Inhibition for Prevention of Mucosal Damage in Celiac Disease
Bana Jabri, M.D., Ph.D.
doi : 10.1056/NEJMe2107502
N Engl J Med 2021; 385:76-77
Audio Interview: Another New Covid-19 Vaccine
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2110939
N Engl J Med 2021; 385:e13
Problems with Using Polygenic Scores to Select Embryos
Patrick Turley, Ph.D., Michelle N. Meyer, Ph.D., J.D., Nancy Wang, S.B., David Cesarini, Ph.D., Evelynn Hammonds, Ph.D., Alicia R. Martin, Ph.D., Benjamin M. Neale, Ph.D., Heidi L. Rehm, Ph.D., Louise Wilkins-Haug, M.D., Ph.D., Daniel J. Benjamin, Ph.D., Steven Hyman, M.D., David Laibson, Ph.D., et al.
doi : 10.1056/NEJMsr2105065
N Engl J Med 2021; 385:78-86
The Placenta — Fast, Loose, and in Control
Joseph F. Costello, Ph.D., and Susan J. Fisher, Ph.D.
doi : 10.1056/NEJMcibr2106321
N Engl J Med 2021; 385:87-89
SARS-CoV-2 Antibody Response in Persons with Past Natural Infection
doi : 10.1056/NEJMc2103825
N Engl J Med 2021; 385:90-92
Sotatercept for Pulmonary Arterial Hypertension
doi : 10.1056/NEJMc2107209
N Engl J Med 2021; 385:92-93
Enfortumab Vedotin in Advanced Urothelial Carcinoma
doi : 10.1056/NEJMc2106975
N Engl J Med 2021; 385:93-94
Extrahepatic Manifestations of Chronic HCV Infection
doi : 10.1056/NEJMc2106143
N Engl J Med 2021; 385:94-96
Once-Weekly Semaglutide in Adults with Overweight or Obesity
doi : 10.1056/NEJMc2106918
N Engl J Med 2021; 385:e4
