One-year access to more than 500 world journals available in the system
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Health Equity and Medicaid Transformation — Operationalizing President Biden’s Agenda
Sara Rosenbaum, J.D.
doi : 10.1056/NEJMp2107222
N Engl J Med 2021; 384:2361-2364
Pregnant Women with Substance Use Disorders — The Harm Associated with Punitive Approaches
Rebecca L. Haffajee, J.D., Ph.D., M.P.H., Laura J. Faherty, M.D., M.P.H., M.S.H.P., and Kara Zivin, Ph.D.
doi : 10.1056/NEJMp2101051
N Engl J Med 2021; 384:2364-2367
Combating Anti-Asian Sentiment — A Practical Guide for Clinicians
James H. Lee, M.D.
doi : 10.1056/NEJMp2102656
N Engl J Med 2021; 384:2367-2369
When Undoing Is Not Enough — Repairing Harms Inflicted on Immigrant Children
N. Ewen Wang, M.D., Ryan Matlow, Ph.D., and Alan Shapiro, M.D.
doi : 10.1056/NEJMp2103956
N Engl J Med 2021; 384:e99
Missing the Point — How Primary Care Can Overcome Covid-19 Vaccine “Hesitancy”
Scott Ratzan, M.D., M.P.A., Eric C. Schneider, M.D., Hilary Hatch, Ph.D., and Joseph Cacchione, M.D.
doi : 10.1056/NEJMp2106137
N Engl J Med 2021; 384:e100
Sotorasib for Lung Cancers with KRAS p.G12C Mutation
Ferdinandos Skoulidis, M.D., Ph.D., Bob T. Li, M.D., Ph.D., M.P.H., Grace K. Dy, M.D., Timothy J. Price, M.B., B.S., D.H.Sc., Gerald S. Falchook, M.D., Jürgen Wolf, M.D., Antoine Italiano, M.D., Martin Schuler, M.D., Hossein Borghaei, D.O., Fabrice Barlesi, M.D., Ph.D., Terufumi Kato, M.D., Alessandra Curioni-Fontecedro, M.D., et al.
doi : 10.1056/NEJMoa2103695
N Engl J Med 2021; 384:2371-2381
Sotorasib showed anticancer activity in patients with KRAS p.G12C–mutated advanced solid tumors in a phase 1 study, and particularly promising anticancer activity was observed in a subgroup of patients with non–small-cell lung cancer (NSCLC).
Acquired Resistance to KRASG12C Inhibition in Cancer
Mark M. Awad, M.D., Ph.D., Shengwu Liu, Ph.D., Igor I. Rybkin, M.D., Ph.D., Kathryn C. Arbour, M.D., Julien Dilly, M.S., Viola W. Zhu, M.D., Ph.D., Melissa L. Johnson, M.D., Rebecca S. Heist, M.D., M.P.H., Tejas Patil, M.D., Gregory J. Riely, M.D., Ph.D., Joseph O. Jacobson, M.D., Xiaoping Yang, Ph.D., et al.
doi : 10.1056/NEJMoa2105281
N Engl J Med 2021; 384:2382-2393
Clinical trials of the KRAS inhibitors adagrasib and sotorasib have shown promising activity in cancers harboring KRAS glycine-to-cysteine amino acid substitutions at codon 12 (KRASG12C). The mechanisms of acquired resistance to these therapies are currently unknown.
Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer
Andrew N.J. Tutt, M.B., Ch.B., Ph.D., Judy E. Garber, M.D., M.P.H., Bella Kaufman, M.D., Giuseppe Viale, M.D., Debora Fumagalli, M.D., Ph.D., Priya Rastogi, M.D., Richard D. Gelber, Ph.D., Evandro de Azambuja, M.D., Ph.D., Anitra Fielding, M.B., Ch.B., Judith Balma?a, M.D., Ph.D., Susan M. Domchek, M.D., Karen A. Gelmon, M.D., et al., for the OlympiA Clinical Trial Steering Committee and Investigators*
doi : 10.1056/NEJMoa2105215
N Engl J Med 2021; 384:2394-2405
Poly(adenosine diphosphate–ribose) polymerase inhibitors target cancers with defects in homologous recombination repair by synthetic lethality. New therapies are needed to reduce recurrence in patients with BRCA1 or BRCA2 germline mutation–associated early breast cancer.
Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans
Jack J. Collier, Ph.D., Claire Guissart, Pharm.D., Monika Ol?hov?, Ph.D., Souphatta Sasorith, Ph.D., Florence Piron-Prunier, M.Sc., Fumi Suomi, Ph.D., David Zhang, M.Sc., Nuria Martinez-Lopez, Ph.D., Nicolas Leboucq, M.D., Angela Bahr, Ph.D., Silvia Azzarello-Burri, M.D., Selina Reich, M.Sc., et al.
doi : 10.1056/NEJMoa1915722
N Engl J Med 2021; 384:2406-2417
Autophagy is the major intracellular degradation route in mammalian cells. Systemic ablation of core autophagy-related (ATG) genes in mice leads to embryonic or perinatal lethality, and conditional models show neurodegeneration. Impaired autophagy has been associated with a range of complex human diseases, yet congenital autophagy disorders are rare.
Azithromycin or Doxycycline for Asymptomatic Rectal Chlamydia trachomatis
Andrew Lau, M.S., Fabian Y.S. Kong, Ph.D., Christopher K. Fairley, Ph.D., David J. Templeton, Ph.D., Janaki Amin, Ph.D., Samuel Phillips, Ph.D., Matthew Law, Ph.D., Marcus Y. Chen, Ph.D., Catriona S. Bradshaw, Ph.D., Basil Donovan, M.D., Anna McNulty, M.D., Mark A. Boyd, M.D., et al.
doi : 10.1056/NEJMoa2031631
N Engl J Med 2021; 384:2418-2427
Rectal chlamydia is a common bacterial sexually transmissible infection among men who have sex with men. Data from randomized, controlled trials are needed to guide treatment.
Stress Incontinence in Women
Jennifer M. Wu, M.D., M.P.H.
doi : 10.1056/NEJMcp1914037
N Engl J Med 2021; 384:2428-2436
Nasal Cauterization with Silver Nitrate for Recurrent Epistaxis
David A. Gudis, M.D., and Zachary M. Soler, M.D.
doi : 10.1056/NEJMvcm2020073
N Engl J Med 2021; 384:e101
Dermatomyositis
Katie A. O’Connell, M.S., and Avery H. LaChance, M.D., M.P.H.
doi : 10.1056/NEJMicm2033425
N Engl J Med 2021; 384:2437
Tongue Discoloration
Paige Seeker, M.D., and Sandra Osswald, M.D.
doi : 10.1056/NEJMicm2100706
N Engl J Med 2021; 384:e102
Case 19-2021: A 54-Year-Old Man with Irritability, Confusion, and Odd Behaviors
Nicholas Kontos, M.D., Michael W. Parsons, Ph.D., Alessandro Biffi, M.D., and R. Gilberto Gonz?lez, M.D., Ph.D.
doi : 10.1056/NEJMcpc2100272
N Engl J Med 2021; 384:2438-2445
Finally, Effective Inhibitors of Mutant KRAS
Neal Rosen, M.D., Ph.D.
doi : 10.1056/NEJMe2107884
N Engl J Med 2021; 384:2447-2449
The Importance of Being Autophagic
Ian Ganley, Ph.D.
doi : 10.1056/NEJMe2107506
N Engl J Med 2021; 384:2449-2450
Audio Interview: A New mRNA Vaccine
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2110531
N Engl J Med 2021; 384:e109
Reducing the Need for HLA-Matched Platelet Transfusion
doi : 10.1056/NEJMc2034764
N Engl J Med 2021; 384:2451-2452
Neutralizing Response against Variants after SARS-CoV-2 Infection and One Dose of BNT162b2
doi : 10.1056/NEJMc2104036
N Engl J Med 2021; 384:2453-2454
Plasma Therapy to Prevent Severe Covid-19 in Older Adults
doi : 10.1056/NEJMc2104747
N Engl J Med 2021; 384:e104
STEP 1 for Effective Weight Control — Another First Step?
doi : 10.1056/NEJMx210007
N Engl J Med 2021; 384:2454
