New England Journal of Medicine




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A Half-Century of Progress in Health: The National Academy of Medicine at 50: Women’s Health — Traversing Medicine and Public Policy

Cynthia A. Stuenkel, M.D., and JoAnn E. Manson, M.D., Dr.P.H.

doi : 10.1056/NEJMp2105292

N Engl J Med 2021; 384:2073-2076

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Institutional Problems, Individual Solutions — The Burden on Black Physicians

Alyssa M. Newman, Ph.D.

doi : 10.1056/NEJMp2103063

N Engl J Med 2021; 384:2076-2078

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Merging Mortalities

Sean Stitham, M.D.

doi : 10.1056/NEJMp2033580

N Engl J Med 2021; 384:2078-2079

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Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke

Richard P. Whitlock, M.D., Ph.D., Emilie P. Belley-Cote, M.D., Ph.D., Domenico Paparella, M.D., Jeff S. Healey, M.D., et al., for the LAAOS III Investigators*

doi : 10.1056/NEJMoa2101897

N Engl J Med 2021; 384:2081-2091

Surgical occlusion of the left atrial appendage has been hypothesized to prevent ischemic stroke in patients with atrial fibrillation, but this has not been proved. The procedure can be performed during cardiac surgery undertaken for other reasons.

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Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

Andreas Greinacher, M.D., Thomas Thiele, M.D., Theodore E. Warkentin, M.D., Karin Weisser, Ph.D., et al.

doi : 10.1056/NEJMoa2104840

N Engl J Med 2021; 384:2092-2101

Several cases of unusual thrombotic events and thrombocytopenia have developed after vaccination with the recombinant adenoviral vector encoding the spike protein antigen of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (ChAdOx1 nCov-19, AstraZeneca). More data were needed on the pathogenesis of this unusual clotting disorder.

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Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma

Dean F. Bajorin, M.D., J. Alfred Witjes, M.D., Jürgen E. Gschwend, M.D., Michael Schenker, M.D., et al.

doi : 10.1056/NEJMoa2034442

N Engl J Med 2021; 384:2102-2114

The role of adjuvant treatment in high-risk muscle-invasive urothelial carcinoma after radical surgery is not clear.

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Meningococcal Serogroup ACWYX Conjugate Vaccine in Malian Toddlers

Milagritos D. Tapia, M.D., Samba O. Sow, M.D., Abdi Naficy, M.D., Fatoumata Diallo, M.D., et al.

doi : 10.1056/NEJMoa2013615

N Engl J Med 2021; 384:2115-2123

Neisseria meningitidis serogroups A, B, C, W, X, and Y cause outbreaks of meningococcal disease. Quadrivalent conjugate vaccines targeting the A, C, W, and Y serogroups are available. A pentavalent vaccine that also includes serogroup X (NmCV-5) is under development.

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Brief Report: Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination

Nina H. Schultz, M.D., Ph.D., Ingvild H. S?rvoll, M.D., Annika E. Michelsen, Ph.D., Ludvig A. Munthe, M.D., Ph.D., et al.

doi : 10.1056/NEJMoa2104882

N Engl J Med 2021; 384:2124-2130

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HIV Infection — Screening, Diagnosis, and Treatment

Michael S. Saag, M.D.

doi : 10.1056/NEJMcp1915826

N Engl J Med 2021; 384:2131-2143

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Gastrointestinal Amyloidosis

Shinji Izuka, M.D., and Hiroyuki Yamashita, M.D., Ph.D.

doi : 10.1056/NEJMicm2034179

N Engl J Med 2021; 384:2144

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Speech-Induced Atrial Tachycardia

André Zimerman, M.D., and Andre d’Avila, M.D., Ph.D.

doi : 10.1056/NEJMicm2030596

N Engl J Med 2021; 384:e83

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Hypertensive Heartbreak

Emily S. Lau, M.D., Benjamin Scirica, M.D., M.P.H., Inga-Marie Schaefer, M.D., Amy L. Miller, M.D., Ph.D., et al.

doi : 10.1056/NEJMcps2018493

N Engl J Med 2021; 384:2145-2152

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The Closing Argument for Surgical Left Atrial Appendage Occlusion

Richard L. Page, M.D.

doi : 10.1056/NEJMe2106069

N Engl J Med 2021; 384:2154-2155

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Audio Interview: Vaccinating Children

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2109334

N Engl J Med 2021; 384:e103

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An Allergic Basis for Abdominal Pain

Marc E. Rothenberg, M.D., Ph.D.

doi : 10.1056/NEJMcibr2104146

N Engl J Med 2021; 384:2156-2158

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Rapid Sequencing-Based Diagnosis of Thiamine Metabolism Dysfunction Syndrome

doi : 10.1056/NEJMc2100365

N Engl J Med 2021; 384:2159-2161

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Cross-Reactive Neutralizing Antibody Responses Elicited by SARS-CoV-2 501Y.V2 (B.1.351)

doi : 10.1056/NEJMc2104192

N Engl J Med 2021; 384:2161-2163

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Mutant UBA1 and Severe Adult-Onset Autoinflammatory Disease

doi : 10.1056/NEJMc2102124

N Engl J Med 2021; 384:2163-2165

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?-Thalassemias

doi : 10.1056/NEJMc2105064

N Engl J Med 2021; 384:2165-2166

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