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The “Legal Epidemiology” of Pandemic Control
Scott Burris, J.D., Evan D. Anderson, J.D., Ph.D., and Alexander C. Wagenaar, M.S.W., Ph.D.
doi : 10.1056/NEJMp2103380
N Engl J Med 2021; 384:1973-1975
A Hidden Opportunity — Medicaid’s Role in Supporting Equitable Access to Clinical Trials
Samuel U. Takvorian, M.D., M.S.H.P., Carmen E. Guerra, M.D., M.S.C.E., and William L. Schpero, Ph.D.
doi : 10.1056/NEJMp2101627
N Engl J Med 2021; 384:1975-1978
Dilemmas of Double Consciousness — On Being Black in Medicine
Ayana L. Langston, M.D.
doi : 10.1056/NEJMp2100211
N Engl J Med 2021; 384:1978-1979
Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease
W. Schuyler Jones, M.D., Hillary Mulder, M.S., Lisa M. Wruck, Ph.D., Michael J. Pencina, Ph.D., Sunil Kripalani, M.D., Daniel Mu?oz, M.D., David L. Crenshaw, L.M.S.W., Mark B. Effron, M.D., Richard N. Re, M.D., Kamal Gupta, M.D., R. David Anderson, M.D., Carl J. Pepine, M.D., Eileen M. Handberg, Ph.D., Brittney R. Manning, M.P.H., Sandeep K. Jain, M.D., Saket Girotra, M.D., Danielle Riley, M.S., Darren A. DeWalt, M.D., Jeff Whittle, M.D., Ythan H. Goldberg, M.D., Veronique L. Roger, M.D., Rachel Hess, M.D., Catherine P. Benziger, M.D., Peter Farrehi, M.D., Li Zhou, M.D., Daniel E. Ford, M.D., Kevin Haynes, Pharm.D., Jeffrey J. VanWormer, Ph.D., Kirk U. Knowlton, M.D., Jennifer L. Kraschnewski, M.D., Tamar S. Polonsky, M.D., Dan J. Fintel, M.D., Faraz S. Ahmad, M.D., James C. McClay, M.D., James R. Campbell, M.D., Douglas S. Bell, M.D., Gregg C. Fonarow, M.D., Steven M. Bradley, M.D., Anuradha Paranjape, M.D., Matthew T. Roe, M.D., Holly R. Robertson, Ph.D., Lesley H. Curtis, Ph.D., Amber G. Sharlow, M.B.A., Lisa G. Berdan, M.H.S., Bradley G. Hammill, Dr.P.H., Debra F. Harris, B.A., Laura G. Qualls, M.S., Guillaume Marquis-Gravel, M.D., Madelaine F. Modrow, M.P.H., Gregory M. Marcus, M.D., Thomas W. Carton, Ph.D., Elizabeth Nauman, Ph.D., Lemuel R. Waitman, Ph.D., Abel N. Kho, M.D., Elizabeth A. Shenkman, Ph.D., Kathleen M. McTigue, M.D., Rainu Kaushal, M.D., Frederick A. Masoudi, M.D., Elliott M. Antman, M.D., Desiree R. Davidson, A.A., Kevin Edgley, M.B.A., James G. Merritt, Ph.D., Linda S. Brown, Doris N. Zemon, R.N., Thomas E. McCormick, III, M.S., Jacqueline D. Alikhaani, B.A., Kenneth C. Gregoire, Russell L. Rothman, M.D., Robert A. Harrington, M.D., and Adrian F. Hernandez, M.D. for the ADAPTABLE Team*
doi : 10.1056/NEJMoa2102137
N Engl J Med 2021; 384:1981-1990
The appropriate dose of aspirin to lower the risk of death, myocardial infarction, and stroke and to minimize major bleeding in patients with established atherosclerotic cardiovascular disease is a subject of controversy.
Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection
Louis Bernard, M.D., Ph.D., Cédric Arvieux, M.D., Benoit Brunschweiler, M.D., Ph.D., Sophie Touchais, M.D., Ph.D., Séverine Ansart, M.D., Ph.D., Jean-Pierre Bru, M.D., Eric Oziol, M.D., Cyril Boeri, M.D., Ph.D., Guillaume Gras, M.D., Jérôme Druon, M.D., Philippe Rosset, M.D., Ph.D., Eric Senneville, M.D., Ph.D., Houcine Bentayeb, M.D., Damien Bouhour, M.D., Gwenaël Le Moal, M.D., Jocelyn Michon, M.D., Hugues Aumaître, M.D., Emmanuel Forestier, M.D., Jean-Michel Laffosse, M.D., Ph.D., Thierry Begué, M.D., Ph.D., Catherine Chirouze, M.D., Ph.D., Fréderic-Antoine Dauchy, M.D., Edouard Devaud, M.D., Benoît Martha, M.D., Denis Burgot, M.D., David Boutoille, M.D., Ph.D., Eric Stindel, M.D., Ph.D., Aurélien Dinh, M.D., Pascale Bemer, M.D., Ph.D., Bruno Giraudeau, Ph.D., Bertrand Issartel, M.D., and Agnès Caille, M.D., Ph.D.
doi : 10.1056/NEJMoa2020198
N Engl J Med 2021; 384:1991-2001
The management of prosthetic joint infection usually consists of a combination of surgery and antimicrobial therapy. The appropriate duration of antimicrobial therapy for this indication remains unclear.
Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency
Donald B. Kohn, M.D., Claire Booth, M.B., B.S., Kit L. Shaw, Ph.D., Jinhua Xu-Bayford, D.I.P., Elizabeth Garabedian, R.N., Valentina Trevisan, M.D., Denise A. Carbonaro-Sarracino, Ph.D., Kajal Soni, B.Sc., Dayna Terrazas, R.N., Katie Snell, B.Sc., Alan Ikeda, M.D., Diego Leon-Rico, Ph.D., Theodore B. Moore, M.D., Karen F. Buckland, Ph.D., Ami J. Shah, M.D., Kimberly C. Gilmour, Ph.D., Satiro De Oliveira, M.D., Christine Rivat, Ph.D., Gay M. Crooks, M.B., B.S., Natalia Izotova, B.Sc., John Tse, Pharm.D., Stuart Adams, Ph.D., Sally Shupien, B.A., Hilory Ricketts, B.Sc., Alejandra Davila, B.S., Chilenwa Uzowuru, M.Sc., Amalia Icreverzi, Ph.D., Provaboti Barman, Ph.D., Beatriz Campo Fernandez, Ph.D., Roger P. Hollis, Ph.D., Maritess Coronel, M.S., Allen Yu, B.S., Krista M. Chun, B.S., Christian E. Casas, B.S., Ruixue Zhang, Ph.D., Serena Arduini, Ph.D., Frances Lynn, M.Sc., Mahesh Kudari, M.B., B.S., Andrea Spezzi, M.D., Marco Zahn, M.Sc., Rene Heimke, M.Sc., Ivan Labik, M.Sc., Roberta Parrott, B.S., Rebecca H. Buckley, M.D., Lilith Reeves, M.S., Kenneth Cornetta, M.D., Robert Sokolic, M.D., Michael Hershfield, M.D., Manfred Schmidt, Ph.D., Fabio Candotti, M.D., Harry L. Malech, M.D., Adrian J. Thrasher, M.B., B.S., and H. Bobby Gaspar, M.B., B.S.
doi : 10.1056/NEJMoa2027675
N Engl J Med 2021; 384:2002-2013
Severe combined immunodeficiency due to adenosine deaminase (ADA) deficiency (ADA-SCID) is a rare and life-threatening primary immunodeficiency.
A Novel Circulating MicroRNA for the Detection of Acute Myocarditis
Rafael Blanco-Dom?nguez, M.Sc., Raquel S?nchez-D?az, Ph.D., Hortensia de la Fuente, M.D., Ph.D., Luis J. Jiménez-Borreguero, M.D., Adela Matesanz-Mar?n, Ph.D., Marta Rela?o, Ph.D., Rosa Jiménez-Alejandre, M.Sc., Beatriz Linillos-Pradillo, M.Sc., Katerina Tsilingiri, Ph.D., Mar?a L. Mart?n-Mariscal, M.D., Laura Alonso-Herranz, Ph.D., Guillermo Moreno, M.Sc., Roberto Mart?n-Asenjo, M.D., Marcos M. Garc?a-Guimaraes, M.D., Katelyn A. Bruno, Ph.D., Esteban Dauden, M.D., Ph.D., Isidoro Gonz?lez-?lvaro, M.D., Ph.D., Luisa M. Villar-Guimerans, M.D., Ph.D., Amaia Mart?nez-Le?n, M.D., Ane M. Salvador-Garicano, Ph.D., Sam A. Michelhaugh, B.A., Nasrien E. Ibrahim, M.D., James L. Januzzi, M.D., Jan Kottwitz, M.D., Sabino Iliceto, M.D., Mario Plebani, M.D., Cristina Basso, M.D., Ph.D., Anna Baritussio, M.D., Ph.D., Mara Seguso, M.Sc., Renzo Marcolongo, M.D., Mercedes Ricote, Ph.D., DeLisa Fairweather, Ph.D., Héctor Bueno, M.D., Ph.D., Leticia Fern?ndez-Friera, M.D., Ph.D., Fernando Alfonso, M.D., Ph.D., Alida L.P. Caforio, M.D., Ph.D., Domingo A. Pascual-Figal, M.D., Ph.D., Bettina Heidecker, M.D., Ph.D., Thomas F. Lüscher, M.D., Ph.D., Saumya Das, M.D., Ph.D., Valent?n Fuster, M.D., Ph.D., Borja Ib??ez, M.D., Ph.D., Francisco S?nchez-Madrid, Ph.D., and Pilar Mart?n, Ph.D.
doi : 10.1056/NEJMoa2003608
N Engl J Med 2021; 384:2014-2027
The diagnosis of acute myocarditis typically requires either endomyocardial biopsy (which is invasive) or cardiovascular magnetic resonance imaging (which is not universally available). Additional approaches to diagnosis are desirable. We sought to identify a novel microRNA for the diagnosis of acute myocarditis.
Immediate “Kangaroo Mother Care” and Survival of Infants with Low Birth Weight
WHO Immediate KMC Study Group
doi : 10.1056/NEJMoa2026486
N Engl J Med 2021; 384:2028-2038
“Kangaroo mother care,” a type of newborn care involving skin-to-skin contact with the mother or other caregiver, reduces mortality in infants with low birth weight (<2.0 kg) when initiated after stabilization, but the majority of deaths occur before stabilization. The safety and efficacy of kangaroo mother care initiated soon after birth among infants with low birth weight are uncertain.
Somatic Mutations in “Benign” Disease
Satu Mustjoki, M.D., and Neal S. Young, M.D.
doi : 10.1056/NEJMra2101920
N Engl J Med 2021; 384:2039-2052
Intraocular Lens Dislocation
Kayla Guidry, D.O.
doi : 10.1056/NEJMicm2032935
N Engl J Med 2021; 384:2053
Isolated Coronary Artery
Marco Loffi, M.D., and Gian B. Danzi, M.D.
doi : 10.1056/NEJMicm2032054
N Engl J Med 2021; 384:e79
Case 16-2021: A 37-Year-Old Woman with Abdominal Pain and Aortic Dilatation
Anahita Dua, M.D., Patrick D. Sutphin, M.D., Ph.D., Mark J. Siedner, M.D., M.P.H., and Jakob Moran, M.D.
doi : 10.1056/NEJMcpc2100278
N Engl J Med 2021; 384:2054-2063
Pragmatic Trials — Need for ADAPTABLE Design
Colin Baigent, F.Med.Sci.
doi : 10.1056/NEJMe2106430
N Engl J Med 2021; 384:2065-2066
Audio Interview: Protecting the Immunosuppressed against Covid-19
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2108949
N Engl J Med 2021; 384:e88
Hidden Biomass of Intact Malaria Parasites in the Human Spleen
doi : 10.1056/NEJMc2023884
N Engl J Med 2021; 384:2067-2069
Avacopan for the Treatment of ANCA-Associated Vasculitis
doi : 10.1056/NEJMc2104672
N Engl J Med 2021; 384:e81
Cryoablation as Initial Therapy for Atrial Fibrillation
doi : 10.1056/NEJMc2103408
N Engl J Med 2021; 384:e82
