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Minority Tax Reform — Avoiding Overtaxing Minorities When We Need Them Most
Theresa Williamson, M.D., C. Rory Goodwin, M.D., Ph.D., and Peter A. Ubel, M.D.
doi : 10.1056/NEJMp2100179
N Engl J Med 2021; 384:1877-1879
Training Future Health Justice Leaders — A Role for Medical–Legal Partnerships
Edward B. Healton, M.D., M.P.H., William M. Treanor, J.D., John J. DeGioia, Ph.D., and Vicki W. Girard, J.D.
doi : 10.1056/NEJMp2100530
N Engl J Med 2021; 384:1879-1881
Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant
Shabir A. Madhi, Ph.D., Vicky Baillie, Ph.D., Clare L. Cutland, Ph.D., Merryn Voysey, D.Phil., Anthonet L. Koen, M.B., B.Ch., Lee Fairlie, F.C.Paeds., Sherman D. Padayachee, M.B., Ch.B., Keertan Dheda, Ph.D., Shaun L. Barnabas, Ph.D., Qasim E. Bhorat, M.Sc., Carmen Briner, M.B., B.Ch., Gaurav Kwatra, Ph.D., Khatija Ahmed, F.C.Path. (Micro), Parvinder Aley, D.Phil., Sutika Bhikha, M.B., B.Ch., Jinal N. Bhiman, Ph.D., As’ad E. Bhorat, F.R.A.C.G.P., Jeanine du Plessis, B.Sc., Aliasgar Esmail, M.D., Marisa Groenewald, M.B., B.Ch., Elizea Horne, M.B., B.Ch., Shi-Hsia Hwa, M.Sc., Aylin Jose, M.B., B.Ch., Teresa Lambe, Ph.D., Matt Laubscher, M.Sc., Mookho Malahleha, M.B., Ch.B., Masebole Masenya, M.B., Ch.B., Mduduzi Masilela, M.B., Ch.B., Shakeel McKenzie, B.Sc., Kgaogelo Molapo, Nat.Dip.O.H.S., Andrew Moultrie, B.Sc., Suzette Oelofse, M.B., Ch.B., Faeezah Patel, M.B., B.Ch., Sureshnee Pillay, B.Sc., Sarah Rhead, M.B., Ch.B., Hylton Rodel, B.Sc., Lindie Rossouw, M.B., B.Ch., Carol Taoushanis, B.Pharm., Houriiyah Tegally, M.Sc., Asha Thombrayil, M.B., B.Ch., Samuel van Eck, R.N., Constantinos K. Wibmer, Ph.D., Nicholas M. Durham, Ph.D., Elizabeth J. Kelly, Ph.D., Tonya L. Villafana, Ph.D., Sarah Gilbert, Ph.D., Andrew J. Pollard, F.Med.Sci., Tulio de Oliveira, Ph.D., Penny L. Moore, Ph.D., Alex Sigal, Ph.D., and Alane Izu, Ph.D. for the NGS-SA Group, and the Wits-VIDA COVID Group*
doi : 10.1056/NEJMoa2102214
N Engl J Med 2021; 384:1885-1898
Assessment of the safety and efficacy of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations is essential, as is investigation of the efficacy of the vaccines against emerging SARS-CoV-2 variants of concern, including the B.1.351 (501Y.V2) variant first identified in South Africa.
Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant
Vivek Shinde, M.D., M.P.H., Sutika Bhikha, M.B., B.S., Zaheer Hoosain, M.B., Ch.B., Moherndran Archary, Ph.D., Qasim Bhorat, M.B., B.Ch., Lee Fairlie, M.B., Ch.B., Umesh Lalloo, M.B., Ch.B., Mduduzi S.L. Masilela, M.B., Ch.B., Dhayendre Moodley, Ph.D., Sherika Hanley, M.B., B.S., Leon Fouche, M.B., Ch.B., Cheryl Louw, M.B., Ch.B., Michele Tameris, M.B., Ch.B., Nishanta Singh, M.B., Ch.B., Ameena Goga, M.B., Ch.B., Keertan Dheda, M.B., B.Ch., Coert Grobbelaar, M.B., Ch.B., Gertruida Kruger, M.B., Ch.B., Nazira Carrim-Ganey, M.B., B.Ch., Vicky Baillie, Ph.D., Tulio de Oliveira, Ph.D., Anthonet Lombard Koen, M.B., Ch.B., Johan J. Lombaard, M.B., Ch.B., Rosie Mngqibisa, M.B., Ch.B., As’ad E. Bhorat, M.B., B.Ch., Gabriella Benadé, M.B., B.S., M.P.H., Natasha Lalloo, M.B., Ch.B., Annah Pitsi, M.B., Ch.B., Pieter-Louis Vollgraaff, M.B., Ch.B., Angelique Luabeya, M.B., Ch.B., Aliasgar Esmail, M.B., Ch.B., Friedrich G. Petrick, M.B., Ch.B., Aylin Oommen-Jose, M.B., Ch.B., Sharne Foulkes, M.B., Ch.B., Khatija Ahmed, M.B., Ch.B., Asha Thombrayil, M.B., Ch.B., Lou Fries, M.D., Shane Cloney-Clark, B.S., Mingzhu Zhu, Ph.D., Chijioke Bennett, M.D., M.P.H., Gary Albert, M.S., Emmanuel Faust, Ph.D., Joyce S. Plested, Ph.D., Andreana Robertson, M.S., Susan Neal, B.S., Iksung Cho, M.S., Greg M. Glenn, M.D., Filip Dubovsky, M.D., M.P.H., and Shabir A. Madhi, M.B., B.Ch., Ph.D. for the 2019nCoV-501 Study Group*
doi : 10.1056/NEJMoa2103055
N Engl J Med 2021; 384:1899-1909
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants threatens progress toward control of the coronavirus disease 2019 (Covid-19) pandemic. In a phase 1–2 trial involving healthy adults, the NVX-CoV2373 nanoparticle vaccine had an acceptable safety profile and was associated with strong neutralizing-antibody and antigen-specific polyfunctional CD4+ T-cell responses. Evaluation of vaccine efficacy was needed in a setting of ongoing SARS-CoV-2 transmission.
Endovascular Therapy for Stroke Due to Basilar-Artery Occlusion
Lucianne C.M. Langezaal, M.D., Erik J.R.J. van der Hoeven, M.D., Ph.D., Francisco J.A. Mont’Alverne, M.D., Ph.D., Jo?o J.F. de Carvalho, M.D., Fabr?cio O. Lima, M.D., Ph.D., Diederik W.J. Dippel, M.D., Ph.D., Aad van der Lugt, M.D., Ph.D., Rob T.H. Lo, M.D., Ph.D., Jelis Boiten, M.D., Ph.D., Geert J. Lycklama à Nijeholt, M.D., Ph.D., Julie Staals, M.D., Ph.D., Wim H. van Zwam, M.D., Ph.D., Paul J. Nederkoorn, M.D., Ph.D., Charles B.L.M. Majoie, M.D., Ph.D., Johannes C. Gerber, M.D., Mikael Mazighi, M.D., Ph.D., Michel Piotin, M.D., Ph.D., Andrea Zini, M.D., Stefano Vallone, M.D., Jeannette Hofmeijer, M.D., Ph.D., Sheila O. Martins, M.D., Ph.D., Christian H. Nolte, M.D., Ph.D., Kristina Szabo, M.D., Ph.D., Francisco A. Dias, M.D., Ph.D., Daniel G. Abud, M.D., Ph.D., Marieke J.H. Wermer, M.D., Ph.D., Michel J.M. Remmers, M.D., Hauke Schneider, M.D., Ph.D., Christina M. Rueckert, M.D., Karlijn F. de Laat, M.D., Ph.D., Albert J. Yoo, M.D., Ph.D., Pieter-Jan van Doormaal, M.D., Adriaan C.G.M. van Es, M.D., Ph.D., Bart J. Emmer, M.D., Ph.D., Patrik Michel, M.D., Ph.D., Volker Puetz, M.D., Heinrich J. Audebert, M.D., Ph.D., Octavio M. Pontes-Neto, M.D., Ph.D., Jan-Albert Vos, M.D., Ph.D., L. Jaap Kappelle, M.D., Ph.D., Ale Algra, M.D., Ph.D., and Wouter J. Schonewille, M.D., Ph.D. for the BASICS Study Group*
doi : 10.1056/NEJMoa2030297
N Engl J Med 2021; 384:1910-1920
The effectiveness of endovascular therapy in patients with stroke caused by basilar-artery occlusion has not been well studied.
Final Report of a Trial of Intensive versus Standard Blood-Pressure Control
The SPRINT Research Group
doi : 10.1056/NEJMoa1901281
N Engl J Med 2021; 384:1921-1930
In a previously reported randomized trial of standard and intensive systolic blood-pressure control, data on some outcome events had yet to be adjudicated and post-trial follow-up data had not yet been collected.
Monoclonal Gammopathy of Renal Significance
Nelson Leung, M.D., Frank Bridoux, M.D., Ph.D., and Samih H. Nasr, M.D.
doi : 10.1056/NEJMra1810907
N Engl J Med 2021; 384:1931-1941
Mitotic and Apoptotic Figures on a Peripheral-Blood Smear
Robert D.H. Markewitz, M.D., and Justina Dargvainiene, M.D.
doi : 10.1056/NEJMicm2033085
N Engl J Med 2021; 384:1942
White Plaque on the Tongue
Deep Chakrabarti, M.D., and Naseem Akhtar, M.S., M.Ch.
doi : 10.1056/NEJMicm2032955
N Engl J Med 2021; 384:e75
Case 15-2021: A 76-Year-Old Woman with Nausea, Diarrhea, and Acute Kidney Failure
Oladapo O. Yeku, M.D., Ph.D., Arielle J. Medford, M.D., Andrew Z. Fenves, M.D., and Sacha N. Uljon, M.D., Ph.D.
doi : 10.1056/NEJMcpc2100274
N Engl J Med 2021; 384:1943-1950
Interplay between Emerging SARS-CoV-2 Variants and Pandemic Control
Kathleen M. Neuzil, M.D., M.P.H.
doi : 10.1056/NEJMe2103931
N Engl J Med 2021; 384:1952-1954
Endovascular Therapy for Basilar-Artery Occlusion — Still Waiting for Answers
Marc Fisher, M.D.
doi : 10.1056/NEJMe2104814
N Engl J Med 2021; 384:1954-1955
Audio Interview: Vaccination in Nursing Homes and New Pulmonary/Critical Care Research
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Jeffrey M. Drazen, M.D., Darren B. Taichman, M.D., Ph.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2108598
N Engl J Med 2021; 384:e89
Circumventing Mutation to Nix Neutropenia
Julia Skokowa, M.D., Ph.D.
doi : 10.1056/NEJMcibr2102952
N Engl J Med 2021; 384:1956-1958
Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine
doi : 10.1056/NEJMc2102051
N Engl J Med 2021; 384:1959-1961
Early Evidence of the Effect of SARS-CoV-2 Vaccine at One Medical Center
doi : 10.1056/NEJMc2102153
N Engl J Med 2021; 384:1962-1963
Thrombotic Thrombocytopenia after Ad26.COV2.S Vaccination
doi : 10.1056/NEJMc2105869
N Engl J Med 2021; 384:1964-1965
Thrombotic Thrombocytopenia after Ad26.COV2.S Vaccination — Response from the Manufacturer
doi : 10.1056/NEJMc2106075
N Engl J Med 2021; 384:1965-1966
Omecamtiv Mecarbil in Systolic Heart Failure
doi : 10.1056/NEJMc2102893
N Engl J Med 2021; 384:1966-1968
BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting
doi : 10.1056/NEJMc2104281
N Engl J Med 2021; 384:1968-1970
The Pathophysiology of Racial Disparities
Amanda Calhoun, M.D., M.P.H.
doi : 10.1056/NEJMpv2105339
N Engl J Med 2021; 384:e78
