New England Journal of Medicine




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Understanding and Mitigating Health Inequities — Past, Current, and Future Directions

Risa J. Lavizzo-Mourey, M.D., M.B.A., Richard E. Besser, M.D., and David R. Williams, Ph.D., M.P.H.

doi : 10.1056/NEJMp2008628

N Engl J Med 2021; 384:1681-1684

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Designing an Independent Public Health Agency

Jacqueline Salwa, B.A., and Christopher Robertson, J.D., Ph.D.

doi : 10.1056/NEJMp2033970

N Engl J Med 2021; 384:1684-1687

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Losing Touch

Ken Wu, M.B., B.S.

doi : 10.1056/NEJMp2033590

N Engl J Med 2021; 384:1687-1689

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Mass-Vaccination Sites — An Essential Innovation to Curb the Covid-19 Pandemic

Eric Goralnick, M.D., M.H.C.M., Christoph Kaufmann, Ph.D., M.B.A., and Atul A. Gawande, M.D., M.P.H.

doi : 10.1056/NEJMp2102535

N Engl J Med 2021; 384:e67

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“Dangling” Accelerated Approvals in Oncology

Julia A. Beaver, M.D., and Richard Pazdur, M.D.

doi : 10.1056/NEJMp2104846

N Engl J Med 2021; 384:e68

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Donanemab in Early Alzheimer’s Disease

Mark A. Mintun, M.D., Albert C. Lo, M.D., Ph.D., Cynthia Duggan Evans, Ph.D., Alette M. Wessels, Ph.D., Paul A. Ardayfio, Ph.D., Scott W. Andersen, M.S., Sergey Shcherbinin, Ph.D., JonDavid Sparks, Ph.D., John R. Sims, M.D., Miroslaw Brys, M.D., Ph.D., Liana G. Apostolova, M.D., Stephen P. Salloway, M.D., and Daniel M. Skovronsky, M.D., Ph.D.

doi : 10.1056/NEJMoa2100708

N Engl J Med 2021; 384:1691-1704

A hallmark of Alzheimer’s disease is the accumulation of amyloid-? (A?) peptide. Donanemab, an antibody that targets a modified form of deposited A?, is being investigated for the treatment of early Alzheimer’s disease.

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Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis

Susan E. Dorman, M.D., Payam Nahid, M.D., M.P.H., Ekaterina V. Kurbatova, M.D., Ph.D., M.P.H., Patrick P.J. Phillips, Ph.D., Kia Bryant, M.P.H., Kelly E. Dooley, M.D., Ph.D., Melissa Engle, C.R.T., C.C.R.C., Stefan V. Goldberg, M.D., Ha T.T. Phan, Dr.P.H., M.D., James Hakim, M.D., John L. Johnson, M.D., Madeleine Lourens, M.B., Ch.B., Ph.D., Neil A. Martinson, M.B., B.Ch., M.P.H., Grace Muzanyi, M.B., Ch.B., Kim Narunsky, M.B., Ch.B., Sandy Nerette, M.D., Nhung V. Nguyen, M.D., Ph.D., Thuong H. Pham, M.D., M.P.H., Samuel Pierre, M.D., Anne E. Purfield, Ph.D., Wadzanai Samaneka, M.B., Ch.B., Radojka M. Savic, Ph.D., Ian Sanne, M.B., B.Ch., D.T.M.H., Nigel A. Scott, M.S., Justin Shenje, M.B., Ch.B., Erin Sizemore, M.P.H., Andrew Vernon, M.D., M.H.S., Ziyaad Waja, M.B., B.Ch., M.P.H., Marc Weiner, M.D., Susan Swindells, M.B., B.S., and Richard E. Chaisson, M.D. for the AIDS Clinical Trials Group and the Tuberculosis Trials Consortium

doi : 10.1056/NEJMoa2033400

N Engl J Med 2021; 384:1705-1718

Rifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis.

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Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined

Julie R. Lundgren, M.D., Ph.D., Charlotte Janus, Ph.D., Simon B.K. Jensen, M.Sc., Christian R. Juhl, M.D., Lisa M. Olsen, M.Sc., Rasmus M. Christensen, B.Sc.Med., Maria S. Svane, M.D., Ph.D., Thomas Bandholm, Ph.D., Kirstine N. Bojsen-M?ller, M.D., Ph.D., Martin B. Blond, M.D., Ph.D., Jens-Erik B. Jensen, M.D., Ph.D., Bente M. Stallknecht, M.D., D.M.Sc., Jens J. Holst, M.D., D.M.Sc., Sten Madsbad, M.D., D.M.Sc., and Signe S. Torekov, Ph.D.

doi : 10.1056/NEJMoa2028198

N Engl J Med 2021; 384:1719-1730

Weight regain after weight loss is a major problem in the treatment of persons with obesity.

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Dexamethasone and Surgical-Site Infection

Tom?s B. Corcoran, M.D., Paul S. Myles, D.Sc., Andrew B. Forbes, Ph.D., Allen C. Cheng, Ph.D., Leon A. Bach, Ph.D., Edmond O’Loughlin, M.Clin.Res., Kate Leslie, M.D., Matthew T.V. Chan, Ph.D., David Story, M.D., Timothy G. Short, M.D., Catherine Martin, Ph.D., Pauline Coutts, P.Grad.Dip.N., and Kwok M. Ho, Ph.D. for the PADDI Investigators, the Australian and New Zealand College of Anaesthetists Clinical Trials Network, and the Australasian Society for Infectious Diseases Clinical Research Network*

doi : 10.1056/NEJMoa2028982

N Engl J Med 2021; 384:1731-1741

The glucocorticoid dexamethasone prevents nausea and vomiting after surgery, but there is concern that it may increase the risk of surgical-site infection.

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Gastric Emptying Abnormalities in Diabetes Mellitus

Raj K. Goyal, M.D.

doi : 10.1056/NEJMra2020927

N Engl J Med 2021; 384:1742-1751

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Hyperpigmentation from Addison’s Disease

Farzahna Mohamed, M.B., B.Ch., and Frederick J. Raal, F.R.C.P., Ph.D.

doi : 10.1056/NEJMicm2018221

N Engl J Med 2021; 384:1752

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Pulmonary Mucormycosis

Leonardo Mejia Buritica, M.D., and Amado J. Karduss Urueta, M.D.

doi : 10.1056/NEJMicm2030205

N Engl J Med 2021; 384:e69

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Inside and Out

Maximilian F. Konig, M.D., Vasanth Sathiyakumar, M.D., Casey M. Phan, M.D., Steven P. Schulman, M.D., and Allan C. Gelber, M.D.

doi : 10.1056/NEJMcps2034360

N Engl J Med 2021; 384:1753-1760

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Progress with Treatments for Alzheimer’s Disease

Allan I. Levey, M.D., Ph.D.

doi : 10.1056/NEJMe2103722

N Engl J Med 2021; 384:1762-1763

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Shortening the Short Course of Tuberculosis Treatment

Eric J. Rubin, M.D., Ph.D., and Valerie Mizrahi, Ph.D.

doi : 10.1056/NEJMe2104499

N Engl J Med 2021; 384:1764-1765

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Audio Interview: India’s Covid-19 Crisis

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Zarir F. Udwadia, M.D., D.N.B., F.C.C.P., F.R.C.P., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2107728

N Engl J Med 2021; 384:e84

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We Shall See?

Vittorio Sebastiano, Ph.D., and Donald J. Zack, M.D., Ph.D.

doi : 10.1056/NEJMcibr2034927

N Engl J Med 2021; 384:1766-1768

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Decoupling Crisis Response from Policing — A Step Toward Equitable Psychiatric Emergency Services

Eric Rafla-Yuan, M.D., Divya K. Chhabra, M.D., and Michael O. Mensah, M.D., M.P.H.

doi : 10.1056/NEJMms2035710

N Engl J Med 2021; 384:1769-1773

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SARS-CoV-2 Infection after Vaccination in Health Care Workers in California

doi : 10.1056/NEJMc2101927

N Engl J Med 2021; 384:1774-1775

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BNT162b2 mRNA Covid-19 Vaccine Effectiveness among Health Care Workers

doi : 10.1056/NEJMc2101951

N Engl J Med 2021; 384:1775-1777

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Duodenal Microbiota in Stunted Undernourished Children with Enteropathy

doi : 10.1056/NEJMc2030388

N Engl J Med 2021; 384:1777-1778

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