New England Journal of Medicine




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No More Surprises — New Legislation on Out-of-Network Billing

Karan R. Chhabra, M.D., Erin Fuse Brown, J.D., M.P.H., and Andrew M. Ryan, Ph.D.

doi : 10.1056/NEJMp2035905

N Engl J Med 2021; 384:1381-1383

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Remote Patient Monitoring — Overdue or Overused?

Keizra Mecklai, B.S., Nicholas Smith, B.S., Ariel D. Stern, Ph.D., and Daniel B. Kramer, M.D., M.P.H.

doi : 10.1056/NEJMp2033275

N Engl J Med 2021; 384:1384-1386

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Race, Policing, and History — Remembering the Freedom House Ambulance Service

Matthew L. Edwards, M.D.

doi : 10.1056/NEJMp2035467

N Engl J Med 2021; 384:1386-1389

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Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial

Rianne van Rijn, M.D., Ph.D., Ivo J. Schurink, B.Sc., Yvonne de Vries, M.D., Ph.D., Aad P. van den Berg, M.D., Ph.D., Miriam Cortes Cerisuelo, M.D., Ph.D., Sarwa Darwish Murad, M.D., Ph.D., Joris I. Erdmann, M.D, Ph.D., Nicholas Gilbo, M.D., Ph.D., Robbert J. de Haas, M.D., Ph.D., Nigel Heaton, M.D., Ph.D., Bart van Hoek, M.D., Ph.D., Volkert A.L. Huurman, M.D., Ph.D., Ina Jochmans, M.D., Ph.D., Otto B. van Leeuwen, Ph.D., Vincent E. de Meijer, M.D., Ph.D., Diethard Monbaliu, M.D., Ph.D., Wojciech G. Polak, M.D., Ph.D., Jules J.G. Slangen, M.D., Roberto I. Troisi, M.D., Ph.D., Aude Vanlander, M.D., Ph.D., Jeroen de Jonge, M.D., Ph.D., and Robert J. Porte, M.D., Ph.D. for the DHOPE-DCD Trial Investigators*

doi : 10.1056/NEJMoa2031532

N Engl J Med 2021; 384:1391-1401

Transplantation of livers obtained from donors after circulatory death is associated with an increased risk of nonanastomotic biliary strictures. Hypothermic oxygenated machine perfusion of livers may reduce the incidence of biliary complications, but data from prospective, controlled studies are limited.

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Trial of Psilocybin versus Escitalopram for Depression

Robin Carhart-Harris, Ph.D., Bruna Giribaldi, B.Sc., Rosalind Watts, D.Clin.Psy., Michelle Baker-Jones, B.A., Ashleigh Murphy-Beiner, M.Sc., Roberta Murphy, M.D., Jonny Martell, M.D., Allan Blemings, M.Sc., David Erritzoe, M.D., and David J. Nutt, M.D.

doi : 10.1056/NEJMoa2032994

N Engl J Med 2021; 384:1402-1411

Psilocybin may have antidepressant properties, but direct comparisons between psilocybin and established treatments for depression are lacking.

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BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

Noa Dagan, M.D., Noam Barda, M.D., Eldad Kepten, Ph.D., Oren Miron, M.A., Shay Perchik, M.A., Mark A. Katz, M.D., Miguel A. Hern?n, M.D., Marc Lipsitch, D.Phil., Ben Reis, Ph.D., and Ran D. Balicer, M.D.

doi : 10.1056/NEJMoa2101765

N Engl J Med 2021; 384:1412-1423

As mass vaccination campaigns against coronavirus disease 2019 (Covid-19) commence worldwide, vaccine effectiveness needs to be assessed for a range of outcomes across diverse populations in a noncontrolled setting. In this study, data from Israel’s largest health care organization were used to evaluate the effectiveness of the BNT162b2 mRNA vaccine.

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Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis

Christopher G. Hughes, M.D., M.S.C.R., Patrick T. Mailloux, D.O., John W. Devlin, Pharm.D., Joshua T. Swan, Pharm.D., M.P.H., Robert D. Sanders, M.D., Antonio Anzueto, M.D., James C. Jackson, Psy.D., Aimee S. Hoskins, B.S.N., R.N., Brenda T. Pun, D.N.P., R.N., Onur M. Orun, M.S., Rameela Raman, Ph.D., Joanna L. Stollings, Pharm.D., Amy L. Kiehl, M.A., Matthew S. Duprey, Pharm.D., Ph.D., Lan N. Bui, Pharm.D., M.P.H., Hollis R. O’Neal, Jr., M.D., Allison Snyder, M.S.N., A.P.R.N., Michael A. Gropper, M.D., Ph.D., Kalpalatha K. Guntupalli, M.D., Gregg J. Stashenko, M.D., Mayur B. Patel, M.D., M.P.H., Nathan E. Brummel, M.D., M.S.C.I., Timothy D. Girard, M.D., M.S.C.I., Robert S. Dittus, M.D., M.P.H., Gordon R. Bernard, M.D., E. Wesley Ely, M.D., M.P.H., and Pratik P. Pandharipande, M.D., M.S.C.I. for the MENDS2 Study Investigators*

doi : 10.1056/NEJMoa2024922

N Engl J Med 2021; 384:1424-1436

Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation. Whether they affect outcomes differentially in mechanically ventilated adults with sepsis undergoing light sedation is unknown.

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Insights into Glomerular Filtration and Albuminuria

Thomas Benzing, M.D., and David Salant, M.D.

doi : 10.1056/NEJMra1808786

N Engl J Med 2021; 384:1437-1446

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Palmoplantar Papules

Benjamin Klein, M.D., and Regina Treudler, M.D.

doi : 10.1056/NEJMicm2032907

N Engl J Med 2021; 384:1447

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Closed Gastroschisis

Tyler D. Robinson, M.D., M.P.H., and Christine Whyte, M.D.

doi : 10.1056/NEJMicm2029281

N Engl J Med 2021; 384:e56

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Case 11-2021: A 39-Year-Old Woman with Fever, Flank Pain, and Inguinal Lymphadenopathy

Richelle C. Charles, M.D., Madeleine Sertic, M.B., Ch.B., Anne M. Neilan, M.D., M.P.H., and Aliyah R. Sohani, M.D.

doi : 10.1056/NEJMcpc2100273

N Engl J Med 2021; 384:1448-1456

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Warming Up to Cold Perfusion

Winfred W. Williams, M.D., and James F. Markmann, M.D., Ph.D.

doi : 10.1056/NEJMe2102056

N Engl J Med 2021; 384:1458-1459

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Back to the Future — The Therapeutic Potential of Psychedelic Drugs

Jeffrey A. Lieberman, M.D.

doi : 10.1056/NEJMe2102835

N Engl J Med 2021; 384:1460-1461

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Audio Interview: Vaccine Successes and Vaccine Adverse Events

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2106379

N Engl J Med 2021; 384:e70

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No Cure without Care — Soothing Science Skepticism

Lisa Rosenbaum, M.D.

doi : 10.1056/NEJMms2101989

N Engl J Med 2021; 384:1462-1465

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Neutralizing Activity of BNT162b2-Elicited Serum

doi : 10.1056/NEJMc2102017

N Engl J Med 2021; 384:1466-1468

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Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine

doi : 10.1056/NEJMc2102179

N Engl J Med 2021; 384:1468-1470

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Cardiovascular Outcomes with Sotagliflozin

doi : 10.1056/NEJMc2102961

N Engl J Med 2021; 384:1470-1473

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Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

doi : 10.1056/NEJMc2100217

N Engl J Med 2021; 384:1473-1474

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Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis

doi : 10.1056/NEJMc2101978

N Engl J Med 2021; 384:1474-1476

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Ewing’s Sarcoma

doi : 10.1056/NEJMc2102423

N Engl J Med 2021; 384:1476-1478

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