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Conquering Atherosclerotic Cardiovascular Disease — 50 Years of Progress
Gary H. Gibbons, M.D., Christine E. Seidman, M.D., and Eric J. Topol, M.D.
doi : 10.1056/NEJMp2033115
N Engl J Med 2021; 384:785-788
Reform of Payment for Primary Care — From Evolution to Revolution
Allan H. Goroll, M.D., Ann C. Greiner, M.C.P., and Stephen C. Schoenbaum, M.D., M.P.H.
doi : 10.1056/NEJMp2031640
N Engl J Med 2021; 384:788-791
Without Sanctuary
S. Michelle Ogunwole, M.D
doi : 10.1056/NEJMp2030623
N Engl J Med 2021; 384:791-793
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
Andre C. Kalil, M.D., M.P.H., Thomas F. Patterson, M.D., Aneesh K. Mehta, M.D., Kay M. Tomashek, M.D., M.P.H., Cameron R. Wolfe, M.B., B.S., M.P.H., Varduhi Ghazaryan, M.D., Vincent C. Marconi, M.D., Guillermo M. Ruiz-Palacios, M.D., Lanny Hsieh, M.D., Susan Kline, M.D., Victor Tapson, M.D., Nicole M. Iovine, M.D., Ph.D., Mamta K. Jain, M.D., M.P.H., Daniel A. Sweeney, M.D., Hana M. El Sahly, M.D., Angela R. Branche, M.D., Justino Regalado Pineda, M.D., David C. Lye, M.B., B.S., Uriel Sandkovsky, M.D., Anne F. Luetkemeyer, M.D., Stuart H. Cohen, M.D., Robert W. Finberg, M.D., Patrick E.H. Jackson, M.D., Babafemi Taiwo, M.B., B.S., Catharine I. Paules, M.D., Henry Arguinchona, M.D., Nathaniel Erdmann, M.D., Ph.D., Neera Ahuja, M.D., Maria Frank, M.D., Myoung-don Oh, M.D., Eu-Suk Kim, M.D., Seow Y. Tan, M.B., B.S., Richard A. Mularski, M.D., M.S.H.S., Henrik Nielsen, M.D., Philip O. Ponce, M.D., Barbara S. Taylor, M.D., LuAnn Larson, R.N., B.S.N., Nadine G. Rouphael, M.D., Youssef Saklawi, M.D., Valeria D. Cantos, M.D., Emily R. Ko, M.D., Ph.D., John J. Engemann, M.D., Alpesh N. Amin, M.D., Miki Watanabe, M.D., Joanne Billings, M.D., M.P.H., Marie-Carmelle Elie, M.D., Richard T. Davey, M.D., Timothy H. Burgess, M.D., M.P.H., Jennifer Ferreira, Sc.M., Michelle Green, M.P.H., Mat Makowski, Ph.D., Anabela Cardoso, M.D., Stephanie de Bono, M.D., Ph.D., Tyler Bonnett, M.S., Michael Proschan, Ph.D., Gregory A. Deye, M.D., Walla Dempsey, Ph.D., Seema U. Nayak, M.D., Lori E. Dodd, Ph.D., and John H. Beigel, M.D. for the ACTT-2 Study Group Members*
doi : 10.1056/NEJMoa2031994
N Engl J Med 2021; 384:795-807
Severe coronavirus disease 2019 (Covid-19) is associated with dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus kinase inhibitor, plus remdesivir are not known.
A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis
Louise China, Ph.D., Nick Freemantle, Ph.D., Ewan Forrest, M.D., Yiannis Kallis, Ph.D., Stephen D. Ryder, D.M., Gavin Wright, Ph.D., Andrew J. Portal, M.D., Natalia Becares Salles, Ph.D., Derek W. Gilroy, Ph.D., and Alastair O’Brien, Ph.D. for the ATTIRE Trial Investigators*
doi : 10.1056/NEJMoa2022166
N Engl J Med 2021; 384:808-817
Infection and increased systemic inflammation cause organ dysfunction and death in patients with decompensated cirrhosis. Preclinical studies provide support for an antiinflammatory role of albumin, but confirmatory large-scale clinical trials are lacking. Whether targeting a serum albumin level of 30 g per liter or greater in these patients with repeated daily infusions of 20% human albumin solution, as compared with standard care, would reduce the incidences of infection, kidney dysfunction, and death is unknown.
Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome
Florence Wong, M.B., B.S., M.D., S. Chris Pappas, M.D., J.D., Michael P. Curry, M.D., K. Rajender Reddy, M.D., Raymond A. Rubin, M.D., Michael K. Porayko, M.D., Stevan A. Gonzalez, M.D., Khalid Mumtaz, M.B., B.S., Nicholas Lim, M.D., Douglas A. Simonetto, M.D., Pratima Sharma, M.D., Arun J. Sanyal, M.B., B.S., M.D., Marlyn J. Mayo, M.D., R. Todd Frederick, M.D., Shannon Escalante, M.S., and Khurram Jamil, M.D. for the CONFIRM Study Investigators*
doi : 10.1056/NEJMoa2008290
N Engl J Med 2021; 384:818-828
The vasoconstrictor terlipressin is used for type 1 hepatorenal syndrome (HRS-1) in many parts of the world and is part of the clinical practice guidelines in Europe.
Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma
Toni K. Choueiri, M.D., Thomas Powles, M.D., Mauricio Burotto, M.D., Bernard Escudier, M.D., Maria T. Bourlon, M.D., Bogdan Zurawski, M.D., Ph.D., Victor M. Oyervides Ju?rez, M.D., James J. Hsieh, M.D., Ph.D., Umberto Basso, M.D., Amishi Y. Shah, M.D., Cristina Su?rez, M.D., Ph.D., Alketa Hamzaj, M.D., Jeffrey C. Goh, M.B., B.S., Carlos Barrios, M.D., Martin Richardet, M.D., Ph.D., Camillo Porta, M.D., Rubén Kowalyszyn, M.D., Juan P. Feregrino, M.D., Jakub ?o?nierek, M.D., Ph.D., David Pook, M.B., B.S., M.D., Elizabeth R. Kessler, M.D., Yoshihiko Tomita, M.D., Ph.D., Ryuichi Mizuno, M.D., Jens Bedke, M.D., Joshua Zhang, M.D., Matthew A. Maurer, M.D., Burcin Simsek, Ph.D., Flavia Ejzykowicz, Ph.D., Gisela M. Schwab, M.D., Andrea B. Apolo, M.D., and Robert J. Motzer, M.D. for the CheckMate 9ER Investigators*
doi : 10.1056/NEJMoa2026982
N Engl J Med 2021; 384:829-841
The efficacy and safety of nivolumab plus cabozantinib as compared with those of sunitinib in the treatment of previously untreated advanced renal-cell carcinoma are not known.
Diffuse Large B-Cell Lymphoma
Laurie H. Sehn, M.D., M.P.H., and Gilles Salles, M.D., Ph.D.
doi : 10.1056/NEJMra2027612
N Engl J Med 2021; 384:842-858
Diagnosis of Achilles’ Tendon Rupture during a Virtual Examination
Stephen Bent, M.D., and Martin J. O’Malley, M.D.
doi : 10.1056/NEJMicm2029689
N Engl J Med 2021; 384:859
Tracheal Agenesis with Bronchoesophageal Fistula
Sihem Darouich, M.D., and Aida Masmoudi, M.D.
doi : 10.1056/NEJMicm2027782
N Engl J Med 2021; 384:e27
A Treacherous Course
Nikolaus Jilg, M.D., Ph.D., Emily S. Lau, M.D., Meghan A. Baker, M.D., Sc.D., Bruce D. Levy, M.D., and Joseph Loscalzo, M.D., Ph.D.
doi : 10.1056/NEJMcps2020668
N Engl J Med 2021; 384:860-865
Baricitinib Therapy in Covid-19 Pneumonia — An Unmet Need Fulfilled
Delia Goletti, M.D., Ph.D., and Fabrizio Cantini, M.D.
doi : 10.1056/NEJMe2034982
N Engl J Med 2021; 384:867-869
Terlipressin and Intravenous Albumin in Advanced Cirrhosis — Friend and Foe
Guadalupe Garcia-Tsao, M.D.
doi : 10.1056/NEJMe2034425
N Engl J Med 2021; 384:869-871
Audio Interview: A New SARS-CoV-2 Vaccine and a New Look at Treatment
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2103680
N Engl J Med 2021; 384:e46
Delayed Second Dose versus Standard Regimen for Covid-19 Vaccination
Siri R. Kadire, M.D., Robert M. Wachter, M.D., and Nicole Lurie, M.D., M.S.P.H.
doi : 10.1056/NEJMclde2101987
N Engl J Med 2021; 384:e28
Misrepresenting Race — The Role of Medical Schools in Propagating Physician Bias
Christina Amutah, B.A., Kaliya Greenidge, Adjoa Mante, A.B., Michelle Munyikwa, Ph.D., Sanjna L. Surya, B.A., Eve Higginbotham, M.D., David S. Jones, M.D., Ph.D., Risa Lavizzo-Mourey, M.D., M.B.A., Dorothy Roberts, J.D., Jennifer Tsai, M.D., M.Ed., and Jaya Aysola, M.D., D.T.M.H., M.P.H.
doi : 10.1056/NEJMms2025768
N Engl J Med 2021; 384:872-878
A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis
doi : 10.1056/NEJMc2035865
N Engl J Med 2021; 384:879-881
Hydroxychloroquine in Hospitalized Patients with Covid-19
doi : 10.1056/NEJMc2035374
N Engl J Med 2021; 384:881-882
Banning Genetic Discrimination in Life Insurance
doi : 10.1056/NEJMc2035871
N Engl J Med 2021; 384:e30
Caring for the Caregivers — Covid-19 Vaccination for Essential Members of the Health Care Team
Meghan C. Halley, Ph.D., M.P.H., and Christina Mangurian, M.D., M.A.S.
doi : 10.1056/NEJMpv2101339
N Engl J Med 2021; 384:e33
